BDH MARINE COLLAGEN PEPTIDES

BDH Marine Collagen Peptides are naturally produced from collagen isolated from fish collagen. Collagen peptides are beneficial to human health due to the presence of essential amino acids such as glycine, proline, hydroxyproline, hydroxylyxine and arginine.

Bone benefits: There is interest in using collagen peptides for strengthening bones or to prevent bone loss. Supplementing with collagen peptides has been shown to improve collagen synthesis. Research suggests that collagen peptides taken after menopause in combination with calcium and vitamin D may reduce bone turnover more than calcium and vitamin D alone.

Skin effects: There is interest in using collagen peptides for reducing skin aging and dry skin. The effects of collagen peptides on skin wrinkles, elasticity, and hydration are thought to be related to down-regulation of the expression and activation of matrix metalloproteinases (MMPs). Research shows MMPs degrade insoluble elastin and catabolize fibrillin microfibrils, leading to lower levels of elastic fibers in the skin. Further studies also shows that collagen peptides can stimulate the production of type II collagen and proteoglycans in chondrocytes. Also, collagen peptides can be metabolized to various dipeptides and can stimulate fibroblasts and chondrocytes to synthesize hyaluronic acid, which helps retain water in both the skin and synovial fluid. Other research suggests that collagen peptides can prevent ultraviolet-induced skin damage by increasing the number of fibroblasts and the density and thickness of collagen fibrils in the skin. A small clinical study in patients with dry skin has shown that oral administration of collagen peptides increases natural moisturizing factor and ceramides, the major components of the stratum corneum that maintain skin moisture, when compared with placebo.

Musculoskeletal effects: Orally, collagen peptides have been shown to increase concentrations of certain collagen-derived dipeptides in the blood. These collagen-derived dipeptides may stimulate and/or protect cells in various connective tissues. It is speculated that this might improve the metabolism of musculoskeletal connective tissue in response to strength training, and may improve resilience against intense exercise. In young, recreationally active females, collagen peptides can increase levels of fat-free mass.

Neurological effects: In middle aged adults, collagen peptides seem to have a small effect on cognitive skills. This may be due to changes in brain structure due to the presence of various amino acids.

Wound healing effects: There is interest in using collagen peptides for wound and burn healing. Collagen peptides have been shown to enhance the growth of skin fibroblasts. In human research, collagen peptides increase serum levels of pre-albumin, a marker of improved nutritional status in patients with burns. The effects of collagen on predictors of survival in burn patients have also been studied. A small clinical study in patients with deep partial thickness or full thickness burns covering 20% to 45% of the total body surface area shows that taking collagen peptides in combination with fish oil for 3 weeks improves high sensitivity C-reactive protein (hs-CRP), but not glucose homeostasis, when compared with placebo.

References:

Alipoor E, Hosseinzadeh-Attar MJ, Salehi S, et al. Effect of Collagen Hydrolysate and Fish Oil on High-Sensitivity C-Reactive Protein and Glucose Homeostasis in Patients with severe Burn; a Randomized Clinical Trial. Arch Acad Emerg Med 2021;9(1):e50.

Jendricke P, Kohl J, Centner C, Gollhofer A, König D. Influence of specific collagen peptides and concurrent training on cardiometabolic parameters and performance indices in women: A randomized controlled trial. Front Nutr. 2020;7:580918.

Jung K, Kim SH, Joo KM, et al. Oral Intake of Enzymatically Decomposed AP Collagen Peptides Improves Skin Moisture and Ceramide and Natural Moisturizing Factor Contents in the Stratum Corneum. Nutrients 2021;13(12):4372.

Koizumi S, Inoue N, Sugihara F, Igase M. Effects of collagen hydrolysates on human brain structure and cognitive function: A pilot clinical study. Nutrients. 2019;12(1):50.